Leukemia Inhibitory Factor and Human Embryo Implantation

摘要: : The success of embryonic implantation relies on an ideal cross-talk between the embryo and receptive endometrium. This article focuses role leukemia inhibitory factor (LIF) its receptors in human implantation. LIF is a secreted glycoprotein first described as that induced differentiation mouse myeloid leukemic M1 cells into macrophages later proposed marker process. An important for was shown knockout mice, when did not occur. In endometrium healthy women, mRNA are expressed throughout menstrual cycle with striking increase midsecretory phase, coinciding supposed window Correlation expression some other markers has been reported. acts by binding to receptor (LIFR) gp130. Human blastocysts express mRNAs LIFR gp130, participating actively establishing contact endometrium, gp130 endometrial epithelium strong phase. Endometrium infertile women produces significantly less during period receptivity. gene mutations unexplained infertility failures IVF patients clear yet. Infertile showed reduced secretion compared fertile controls window. Recombinant might help improve rate infertility.