DERIVATION OF OOCYTES FROM MOUSE EMBRYONIC STEM CELLS

摘要: Continuation of mammalian species requires the formation and development sexually dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent rather than totipotent because failure to detect germline under differentiating conditions. Here we show that mouse in culture can develop into oogonia enter meiosis, recruit adjacent form follicle-like structures, later blastocysts. Oogenesis should contribute various areas, including nuclear transfer manipulation line, advance studies on fertility treatment somatic cell interaction differentiation. In early embryo, line soma indistinguishable from each other. mouse, competence is induced at day 6.5 proximal epiblast by signals emanating