Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling.
作者： Shinichiro Chuma , Norio Nakatsuji
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摘要: Mouse primordial germ cells (PGCs) arrive at the urogenital ridge (UGR) around 10.5 days postcoitum (dpc). They proliferate until 13.5 dpc, then enter into meiosis in female or become mitotically arrested male gonads. In this study, meiotic transition of mouse PGCs was examined vitro. Female obtained from UGRs genital ridges 10.5-11.5 dpc began to express meiosis-specific genes, Scp3 and Dmc1, after dissociation cultivation on feeder for several days. Meiotic leptotene stage confirmed by formation axial cores. Male migratory mesenteries also expressed formed cores culture, supporting hypothesis that are capable entering before arriving UGR. gp130-mediated signaling, known promote survival/growth inhibit differentiation embryonic stem cells, suppressed expression inhibited following This novel activity signaling may provide some clues understanding pluripotency mammalian germ-line and/or sex fetal cells.
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Tetsuya Taga, Masahiko Hibi, Yuuichi Hirata, Katsuhiko Yamasaki, Kiyoshi Yasukawa, Tadashi Matsuda, Toshio Hirano, Tadamitsu Kishimoto, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell. ,vol. 58, pp. 573- 581 ,(1989) , 10.1016/0092-8674(89)90438-8
Maurizio Pesce, Xiangyuan Wang, Debra J Wolgemuth, Hans R Schöler, Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation Mechanisms of Development. ,vol. 71, pp. 89- 98 ,(1998) , 10.1016/S0925-4773(98)00002-1
K. Yoshida, T. Taga, M. Saito, S. Suematsu, A. Kumanogoh, T. Tanaka, H. Fujiwara, M. Hirata, T. Yamagami, T. Nakahata, T. Hirabayashi, Y. Yoneda, K. Tanaka, W. Z. Wang, C. Mori, K. Shiota, N. Yoshida, T. Kishimoto, Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 407- 411 ,(1996) , 10.1073/PNAS.93.1.407
I. Godin, R. Deed, J. Cooke, K. Zsebo, M. Dexter, C. C. Wylie, Effects of the Steel Gene Product on Mouse Primordial Germ Cells in Culture Nature. ,vol. 352, pp. 807- 809 ,(1991) , 10.1038/352807A0
Douglas J. Hilton, Nicholas M. Gough, Leukemia inhibitory factor: A biological perspective Journal of Cellular Biochemistry. ,vol. 46, pp. 21- 26 ,(1991) , 10.1002/JCB.240460105
Anne McLaren, Germline and soma: interactions during early mouse development Seminars in Developmental Biology. ,vol. 5, pp. 43- 49 ,(1994) , 10.1006/SEDB.1994.1006
A. Duncan Chiquoine, The identification, origin, and migration of the primordial germ cells in the mouse embryo. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 118, pp. 135- 146 ,(1954) , 10.1002/AR.1091180202
T. Matsuda, STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells The EMBO Journal. ,vol. 18, pp. 4261- 4269 ,(1999) , 10.1093/EMBOJ/18.15.4261
R. Lindsay Williams, Douglas J. Hilton, Shirley Pease, Tracy A. Willson, Colin L. Stewart, David P. Gearing, Erwin F. Wagner, Donald Metcalf, Nicos A. Nicola, Nicholas M. Gough, Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells Nature. ,vol. 336, pp. 684- 687 ,(1988) , 10.1038/336684A0
Massimo De Felici, Susanna Dolci, Leukemia inhibitory factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers. Developmental Biology. ,vol. 147, pp. 281- 284 ,(1991) , 10.1016/S0012-1606(05)80025-9