Utilization of shape memory in external vein-graft meshes allows extreme diameter constriction for suppressing intimal hyperplasia: A non-human primate study

摘要: Objective Constrictive external Nitinol meshes have been shown to suppress neointimal tissue formation and preserve endothelial integrity in vein grafts. As this mitigating effect increased with the degree of constriction, we investigated whether extreme constriction was possible without leading detrimental luminal encroachment. Methods A senescent non-human primate model (Chacma baboons/bilateral femoral interposition grafts) mimicking clinical size-mismatch between grafts run-off arteries used. Control were either untreated (group 1) or spray-coated fibrin glue 2). constricting lumen by ≤80% 3) compared longitudinally pleated identical circumference that constricted >90% 4). Anastomotic size mismatch at implantation expressed as quotient cross-sectional area artery graft (Q C ). Results At 6 months, all mesh support showed thick eccentric layers 1: 348 ± 130 μm [Q median implant 0.19]; group 2: 318 142 0.17]). Fibrin glue-spraying had no effect. In contrast, absent mesh-supported ( P 1.47]; 4: 1.3 0.6 3.8 5.6 3.09]). Except for mild buckling (fold height Conclusion Extreme using is buckling. Although moderate found be sufficient diffuse intimal hyperplasia detachment, extremer may occasionally required eliminate irregularities.