The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cis-platin (BEP)

摘要: Between July 1979 and December 1981, 43 patients with metastatic germ-cell tumours (36 testicular non-seminomas 7 seminomas) were treated 2-6 cycles of bleomycin, etoposide cis-platin (BEP). Forty (93%) are alive, 37 (86%) no evidence disease. Of 36 men non-seminoma 30 (83.3%) alive disease-free at 8-38 months (median 17.0 months). In the latter group 25/28 (89.3%) who had prior irradiation disease-free. Fourteen small volume metastases 13 in complete remission, as 12/14 bulky All advanced seminoma It is concluded that BEP a well tolerated effective first line treatment for tumours.