Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord?

作者: G. W. Price , G. P. Wilkin , M. J. Turnbull , N. G. Bowery

DOI: 10.1038/307071A0

关键词: Postsynaptic potentialNeuroscienceBaclofenSpinal cordCentral nervous systemGABAB receptorNeurotransmitterGABA receptorBiologyGABAA receptorAnatomy

摘要: The site of action the antispastic drug baclofen has long been considered to reside in spinal cord although supraspinal effects have also reported. This beta-chlorophenyl derivative neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission possibly through a decrease transmitter release rather than by any antagonism at postsynaptic receptors. Recently, shown be selective ligand for bicuculline-insensitive GABA receptor (GABAB) that occurs widely mammalian central nervous system including cord. apparent importance therapeutic this prompted us ask whether they involve GABAB activation. As an initial step we located these receptors autoradiography, comparing them with classical GABAA sites. We report here sites, unlike are present high concentrations laminae I, II, III IV dorsal horn after neonatal administration capsaicin binding is reduced 40-50%.

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