pS2 Protein Expression in Gastric Carcinoma. An Immunohistochemical and Immunoradiometric Study

摘要: The aim of this study was to examine the prevalence pS2 expression in gastric carcinoma and determine its prognostic significance. We analysed protein 50 carcinomas respective adjacent mucosas by immunohistochemistry immunoradiometric assay (IRMA). consistently expressed superficial foveolar epithelium non-neoplastic mucosa 66.0% carcinomas. immunoreactivity significantly higher diffuse than intestinal carcinomas, those cases with nodal metastases without. No correlation found between immunostaining gender, age, staging, depth wall penetration, venous invasion, ploidy S-phase fraction. mean levels (IRMA) were lower mucosas, not correlated any aforementioned clinicopathological features. survival patients pS2-positive tumours different from that pS2-negative tumours. conclude expression, which can be used as a marker gastric-type differentiation, is associated type. lack most features tumour aggressiveness patients' precludes use tool carcinoma.