Somatic mutations of the trefoil factor family 1 gene in gastric cancer.
作者： Won Sang Park , Ro Ra Oh , Jik Young Park , Jong Heun Lee , Min Sun Shin
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摘要: Abstract Background & Aims: There is increasing evidence that trefoil factor family 1 (TFF1) a stabilizer of the mucous gel overlying gastrointestinal mucosa provides physical barrier against various noxious agents. TFF1 knockout mice developed multiple gastric adenomas and carcinomas, suggesting gastric-specific tumor-suppressor gene. Methods: We analyzed somatic mutations loss heterozygosity (LOH) gene using an intragenic polymorphic marker in 61 tumors. The expression pattern was also examined by immunohistochemistry. Results: detected total 8 mutations—1 (5.5%) 18 7 (16.3%) 43 carcinomas—that were all missense confined to loop I II structure . LOH 5 (1 adenoma 4 cancer) 30 (16.7%) informative tumors with −2 base pairs (bp) upstream coding region Although 2 cases noninformative, cancers mutation seemed show remaining allele except case, found 44.2% but there no correlation between immunoreactivity genetic alterations Conclusions: These results indicate may lead mucosal defects contribute pathogenesis cancer. GASTROENTEROLOGY 2000;119:691-698
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