Palonosetron–5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure
作者： Kerry L. Price , Reidun K. Lillestol , Chris Ulens , Sarah C. R. Lummis
DOI: 10.1021/ACSCHEMNEURO.6B00132
关键词: Chemistry 、 Acetylcholine binding 、 Stereochemistry 、 Binding site 、 Binding protein 、 Palonosetron 、 Ligand-gated ion channel 、 Receptor antagonist 、 5-HT3 receptor 、 Cooperative binding
摘要: … Superimposition of palonosetron (sticks) and granisetron (wireframe) as found in the crystal … cation−π interaction R92 forms with the indazole portion of granisetron, which is apparent …
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