Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction.

摘要: This review focuses on the biological action of compounds from group substituted 1,3,4-thiadiazines stress response and myocardial infarction. The aim this is to propose possible mechanisms offer prospectives in development new derivatives as therapeutic agents. It known, that have effects similar those used antidepressants can down-regulate secretion proinflammatory cytokines, up-regulate release anti-inflammatory ones affect cell recruitment, which allows them be considered immunomodulators well. results pharmacological evaluation, silico studies, vivo experiments several with antidepressant properties are presented. proposed cardioprotective might explained by peculiarities their multi-target action: ability interact various types receptors transporters dopaminergic, serotonergic acetylcholinergic systems block kinase signal pathway PI3K-AKT. described suggest it necessary search for a agents limiting peripheral inflammatory/ischemic damage through entral reaction modifying pro-inflammatory cytokine signaling pathways brain.