Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice
作者： Wenjiao Jiang , Qianying Chen , Peijin Li , Qianfeng Lu , Xue Pei
DOI: 10.1016/J.BIOPHA.2016.12.033
关键词:
摘要: Magnesium Isoglycyrrhizinate (MI) is a magnesium salt of 18α-GA stereoisomer which has been reported to exert hepatoprotective activity. The aim the present study was ascertain underlying mechanisms behind action on neuroinflammatation and oxidative stress in LPS-stimulated mice. Mice were pretreated with (MI, 25, 50mg/kg) as well fluoxetine (Flu, positive control, 20mg/kg) once daily for one week before intraperitoneal injection LPS (0.83mg/kg). Pretreatments MI Flu significantly improved immobility time tail suspension test (TST) forced swim (FST) locomotor activity open-field (OFT). In addition, levels pro-inflammatory cytokines serum hippocampus also suppressed effectively by administrations. Western blot analysis showed up-regulated p-Jak3, p-STAT3, p-NF-κBp65, p-IκBα mice exposed LPS, while different degrees down-regulation these expression observed (25, (20mg/kg) groups respectively. Taken together, our obtained results demonstrated that exhibited an antidepressant-like effect LPS-induced mice, might be mediated JAK/STAT/NF-κB signaling pathway.
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