Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats.
作者： Árpád Kovács , Gábor Á Fülöp , Andrea Kovács , Tamás Csípő , Beáta Bódi
DOI: 10.1152/AJPHEART.00842.2015
关键词: Stiffness 、 Passive stiffness 、 Diastole 、 Renin–angiotensin system 、 Cardiology 、 Relaxation (psychology) 、 Titin 、 Rats sprague dawley 、 Medicine 、 Internal medicine 、 Endocrinology
摘要: It is shown that activation of the renin-angiotensin-aldosterone system leads to hypertension and impaired cardiac relaxation associated with increased cardiomyocyte stiffness hyperphosphorylat...
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