Safety and perception: What are the greatest enemies of HPV vaccination programmes?

摘要: Vaccines stimulate a person's immune system to produce an adequate reaction against specific infectious agent; i.e. the person is protected from that disease without having get it first. As vaccines are administrated healthy subjects, they held highest standards of safety. Regarding human papillomavirus (HPV) vaccines, at present three prophylactic licensed (bivalent HPV 16/18, quadrivalent 6/11/16/18 and nonovalent 6/11/16/18/31/33/45/52/58 vaccine). Pre- post-licensure studies (i.e. not yet for vaccine) confirm generally safe well-tolerated, site injections symptoms most common adverse events (AEs) reported, pain frequently referred local symptom. Serious AEs rare associated with severe sequelae, least no vaccine-related deaths have occurred. Despite these scientific evidences, still difficult explain population importance good vaccination programme. There many determinants hesitancy which represent barrier must be overcome in order increase vaccine coverage, including psychological reactions, religious or cultural aspects, fear possible (demyelinating diseases, Complex Regional Pain Syndrome - CRPS, Postural Orthostatic Tachycardia POTS). A weak communication strategy suffers due spread unverified news by media websites may lead failure Such situation happened Japan (2013), great number women remain vulnerable HPV-related cancers. In resolve issues around acceptance, necessary use strategies. Multicomponent dialogue-based interventions seem effective, especially if language used, customized according programme target.