A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women
作者： Elmar A Joura , Anna R Giuliano , Ole-Erik Iversen , Celine Bouchard , Constance Mao
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摘要: BackgroundThe investigational 9-valent viruslike particle vaccine against human papillomavirus (HPV) includes the HPV types in quadrivalent (qHPV) (6, 11, 16, and 18) five additional oncogenic (31, 33, 45, 52, 58). Here we present results of a study efficacy immunogenicity 9vHPV women 16 to 26 years age. MethodsWe performed randomized, international, double-blind, phase 2b–3 14,215 women. Participants received or qHPV series three intramuscular injections on day 1 at months 2 6. Serum was collected for analysis antibody responses. Swabs labial, vulvar, perineal, perianal, endocervical, ectocervical tissue were obtained used DNA testing, liquid-based cytologic testing (Papanicolaou testing) regularly. Tissue by means biopsy as part definitive therapy (including loop electrosurgical excision procedure c...
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