Notch signaling in serous ovarian cancer.
作者： Jolijn W Groeneweg , Rosemary Foster , Whitfield B Growdon , René HM Verheijen , Bo R Rueda
DOI: 10.1186/S13048-014-0095-1
关键词: Ovarian carcinoma 、 Notch signaling pathway 、 Epithelial–mesenchymal transition 、 Gamma secretase 、 Ovary 、 Biology 、 Disease 、 Oncology 、 Ovarian cancer 、 Serous fluid 、 Internal medicine
摘要: Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors. While cytoreductive surgery followed by platinum based are initially effective, ovarian tumors have a high propensity to recur highlighting distinct need for novel therapeutics improve outcomes affected women. The Notch signaling pathway plays an established role in embryologic development deregulation this cascade has been linked many cancers. Recent genomic profiling serous carcinoma revealed that alterations among prevalent detected changes. A growing body scientific literature confirmed heightened activity carcinoma, utilized vitro vivo models suggest targeting gamma secretase inhibitors (GSIs) leads anti-tumor effects. it currently unknown if inhibition can offer clinical benefit cancer, several GSIs phase I II trials across sites including ovary. This review will provide background on function focus pre-clinical links altered progression.
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