Pulmonary nodules resembling bronchioloalveolar carcinoma in adolescent cancer patients.

摘要: Pulmonary nodules morphologically indistinguishable from bronchioloalveolar carcinoma (BAC) were found in two adolescent cancer patients postchemotherapy. A solitary nodule was noted at thoracotomy for a single computerized tomography (CT) scan lesion 16-yr-old male, 6 yr after diagnosis of Ewing's sarcoma. similar 19-yr-old male coincident with resection multiple lung metastases testicular germ cell tumor. Both lesions discrete nodular masses (1 cm and 0.5 cm) consisting atypical epithelial cells papillary lepidic growth pattern surrounded by histologically normal appearing lung. Immunohistochemistry both cases positive laminoorganel (LO) antigen, which is type II pneumocytes, one showed carcinoembryonic antigen (CEA) staining. Quantitative DNA analysis case indicated aneuploidy. Thus the morphology, immunohistochemistry, content these suggest that they may represent early cancers despite highly unusual clinical context. The extreme rarity BAC this age group makes report significant light heightening concern about second malignancies pediatric reports chemically induced pulmonary adenomas mice. It also underscores importance basing therapeutic decisions on histologic rather than assuming presence metastatic disease.