Expression of the TSLC1 Adhesion Molecule in Pulmonary Epithelium and Its Down-Regulation in Pulmonary Adenocarcinoma Other than Bronchioloalveolar Carcinoma

摘要: TSLC1 (tumor suppressor in lung cancer-1) is an adhesion molecule of the Ig superfamily that binds homophilically and mediates cell-cell interactions. Originally, was cloned as a candidate tumor from genomic region frequently exhibits loss heterogeneity human non-small-cell cancer (NSCLC). However, there have been no studies on expression normal lungs or NSCLC. Here we show pulmonary epithelial cells express its levels are often decreased lost primary adenocarcinoma, major histologic type Immunohistochemistry revealed localized at boundaries all columnar mouse embryonic 10.5 13 days postcoitus. Similar staining patterns were observed bronchiolar alveolar adult lungs, suggesting physiologic role for interactions these cells. Next performed Western blot analyses 47 adenocarcinomas judged each either nondecreased by comparing with lungs. The profiles had significant relation to subtypes but not other clinicopathologic parameters. Sixteen bronchioloalveolar carcinomas (BACs) nondecreased, while 19 31 (63%) than BAC (p < 0.0001). tumors only also lepidic growth components expressed their lateral plasma membranes. These considered less invasive because they proliferate pattern along walls. Thus, present results support hypothesis NSCLC suggest preserved integrity may contribute phenotypes