Structure-Switching Signaling Aptamers

作者: Razvan Nutiu , Yingfu Li

DOI: 10.1021/JA028962O

关键词: FluorophoreQuenching (fluorescence)OligonucleotideNucleic acidDuplex (building)NanotechnologyCombinatorial chemistryAptamerDNAProtein tertiary structureChemistry

摘要: … the above signaling aptamer is achieved because the original RNA aptamer has a … aptamer into two molecules. Therefore, it can be difficult to use the same strategy for other aptamers …

参考文章(25)
Sulay Jhaveri, Manjula Rajendran, Andrew D. Ellington, In vitro selection of signaling aptamers Nature Biotechnology. ,vol. 18, pp. 1293- 1297 ,(2001) , 10.1038/82414
David E. Huizenga, Jack W. Szostak, A DNA aptamer that binds adenosine and ATP. Biochemistry. ,vol. 34, pp. 656- 665 ,(1995) , 10.1021/BI00002A033
Christopher P. Rusconi, Elizabeth Scardino, Juliana Layzer, George A. Pitoc, Thomas L. Ortel, Dougald Monroe, Bruce A. Sullenger, RNA aptamers as reversible antagonists of coagulation factor IXa. Nature. ,vol. 419, pp. 90- 94 ,(2002) , 10.1038/NATURE00963
Milan N. Stojanovic, Paloma de Prada, Donald W. Landry, Aptamer-Based Folding Fluorescent Sensor for Cocaine Journal of the American Chemical Society. ,vol. 123, pp. 4928- 4931 ,(2001) , 10.1021/JA0038171
Jörg S. Hartig, S. Hani Najafi-Shoushtari, Imke Grüne, Amy Yan, Andrew D. Ellington, Michael Famulok, Protein-dependent ribozymes report molecular interactions in real time Nature Biotechnology. ,vol. 20, pp. 717- 722 ,(2002) , 10.1038/NBT0702-717
Sulay D. Jhaveri, Romy Kirby, Rick Conrad, Emily J. Maglott, Michael Bowser, Robert T. Kennedy, Gary Glick, Andrew D. Ellington, Designed signaling aptamers that transduce molecular recognition to changes in fluorescence intensity Journal of the American Chemical Society. ,vol. 122, pp. 2469- 2473 ,(2000) , 10.1021/JA992393B
R. Jenison, S. Gill, A Pardi, B Polisky, High-resolution molecular discrimination by RNA Science. ,vol. 263, pp. 1425- 1429 ,(1994) , 10.1126/SCIENCE.7510417
P. E. Batson, N. Dellby, O. L. Krivanek, Erratum: corrigendum: Sub-ångstrom resolution using aberration corrected electron optics Nature. ,vol. 419, pp. 94- 94 ,(2002) , 10.1038/NATURE01058
Milan N. Stojanovic, Paloma de Prada, Donald W. Landry, Fluorescent Sensors Based on Aptamer Self-Assembly Journal of the American Chemical Society. ,vol. 122, pp. 11547- 11548 ,(2000) , 10.1021/JA0022223