Dual-frequency acoustic droplet vaporization detection for medical imaging

摘要: Liquid-filled perfluorocarbon droplets emit a unique acoustic signature when vaporized into gas-filled microbubbles using ultrasound. Here, we conducted pilot study in tissue-mimicking flow phantom to explore the spatial aspects of droplet vaporization and investigate effects applied pressure concentration on image contrast axial lateral resolution. Control microbubble agents were used for comparison. A confocal dual-frequency transducer was transmit at 8 MHz passively receive 1 MHz. Droplet signals significantly higher energy than signals. This resulted improved signal separation high contrast-to-tissue ratios (CTR). Specifically, with peak negative (PNP) 450 kPa focus, CTR B-mode images 18.3 dB -0.4 microbubbles. The resolution dictated by size activation area, lower pressures resulting smaller areas (0.67 mm kPa). initial independent properties pulse (3.86 In post-processing, time-domain averaging (TDA) (640 700 Taken together, these results indicate that it is possible generate high-sensitivity, high-contrast events. future, this has potential be combination dropletmediated therapy track treatment outcomes or as standalone diagnostic system monitor physical surrounding environment.