Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound.

摘要: Background: As one of the most effective triggers with high tissue-penetrating capability and non-invasive feature, ultrasound shows great potential for controlling drug release enhancing chemotherapeutic efficacy. In this study, we report, first time, construction a phase-changeable drug-delivery nanosystem programmable low-intensity focused (LIFU) that could trigger drug-release significantly enhance anticancer delivery. Methods: Liquid-gas perfluorocarbon (perfluoropentane) an (doxorubicin) were simultaneously encapsulated in two kinds nanodroplets. By triggering LIFU, nanodroplets be converted into microbubbles locally tumor tissues acoustic imaging loaded was released after microbubble collapse. Based on property shell materials, such as stiffness, types (lipid-based PLGA-based nanodroplets) activated by different pressure levels. Ultrasound irradiation duration power LIFU tested selected to monitor control from Various energies introduced induce phase transition collapse vitro (3 W/3 min lipid nanodroplets; 8 PLGA nanodroplets). Results: We detected three steps drug-releasing profiles exhibiting patterns. Importantly, intratumoral accumulation distribution exposure enhanced, proliferation substantially inhibited. Co-delivery drug-loaded overcome physical barriers during chemotherapy. Conclusion: Our study provides new strategy efficient ultrasound-triggered chemotherapy nanocarriers capable achieving on-demand release.