The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs
作者： Adair L. Borges , Alan R. Davidson , Joseph Bondy-Denomy
DOI: 10.1146/ANNUREV-VIROLOGY-101416-041616
关键词: Bacteriophage 、 Biology 、 CRISPR 、 Plasmid 、 Genome editing 、 Function (biology) 、 Gene 、 Cas9 、 Genetics 、 Protein family
摘要: Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infection by bacteriophages (phages). These RNA-guided nucleases are powerful weapons in the fight against foreign DNA, such as phages plasmids, well a revolutionary gene editing tool. Phages not passive bystanders their interactions with systems, however; recent discoveries have described phage genes that inhibit function. More than 20 protein families, previously of unknown function, been ascribed anti-CRISPR Here, we discuss how these inhibitors were discovered modes action elucidated. We also consider potential impact anti-CRISPRs on bacterial evolution. Finally, speculate about future this field.
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