STUDIES ON THE BLOOD-BRAIN BARRIER WITH RADIOACTIVE PHOSPHORUS

摘要: RADIOACTIVE isotopes are being used with increasing frequency to localize brain tumors. Either the locally increased permeability of blood-brain barrier or active metabolism tumors—it is not at present clear which— causes a higher concentration some in tissue neoplasm than normal brain. The investigations Hevesy and Hahn 1 showed that only small fraction radioactive phosphorus (P 32 ), approximately 0.02% total amount, given parenterally, deposited This finding was considered evidence slow turnover central nervous system. Lindberg I, 2 working on theory plays decisive role this phenomenon, injected P directly into cerebrospinal fluid, bypassing barrier, found isotope would indeed accumulate rapidly After such an injection cisterna magna (cisterna cerebellomedullaris)