Methods for cell genotyping
作者： Cengiz Cinnioglu , Johan Baner , Zachary P. Demko , Matthew Rabinowitz , David S. Johnson
DOI:
关键词: Ploidy 、 Allele 、 Cell 、 Haplotype 、 Genetics 、 Biology 、 Genotyping 、 Whole Genome Amplification 、 Context (language use) 、 DNA
摘要: Methods for cell genotyping are disclosed herein. A method determining the genomic data of one or a small number cells, from fragmentary DNA, where limited quantity genetic is available may include adding more targeted primers to whole genome amplification cell, increasing accuracy with which key alleles measured in context amplification. The material single be divided into fractions, each separately genotyped, allowing reconstruction cells haplotype. and distribution various different fractions used determine ploidy state plurality chromosomes cell.
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