Age-dependent neurotoxicity in rats chronically exposed to low level lead ingestion: phospholipid metabolism in synaptosomes and microvessels.
作者： Ashok K. Singh
DOI: 10.1177/074823379401000106
关键词: Significant difference 、 Neurotoxicity 、 Chemistry 、 Membrane 、 Age dependent 、 Internal medicine 、 Endocrinology 、 Metabolism 、 Chronic exposure 、 Biochemistry 、 Ingestion 、 Phospholipid
摘要: The uptake of [3H]Ch and [3H]MI by synaptosomes or microvessels, the concentration membrane phospholipids, incorporation into respective phospholipids in were studied samples obtained from brain control rats exposed to a low-level lead ingestion starting prenatally, neonatally at an adult age. Vmax values for control-neonatal control-adult significantly different. However, there was no significant difference samples. same true Km [3H]MI. Chronic exposure embryonic neonatal inhibited rate [3H]Mi reduced concentrations Ch MI membranes these tissues, did not effect phospholipids. In rats, changes observed following chronic exposure. These observations suggest that transport mechanisms are sensitive but not. A lead-induced decrease availability may be responsible
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