Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases.

摘要: Pulmonary enteric adenocarcinoma (PEAC), a extremely rare variant of primary invasive the lung, was recognized by international multidisciplinary classification lung which proposed International Association for Study Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory (ERS) published in early 2011. Histologically, PEAC is considered to be mainly composed tall columnar cells arranged an irregular glandular cavity or cribriform pattern with extensive central necrosis show high resemblance that intestinal epithelia colorectal carcinomas. Immunohistochemically, can not only expresses typical proteins common primaries but positive at least one markers, such as CDX2, cytokeratin (CK) 20, MUC2, therefore, differentiation PEACs from metastatic cancers challenging. In this study, we report 9 cases panel immunohistochemical protein markers CK7, CK20, thyroid transcription factor 1 (TTF-1), Napsin A, MUC2 villin analyzed comparison 20 carcinomas (MCRs), adenocarcinomas (tPACs). As expected, CK7 expression documented all tPCAs while CK20 significantly more prevalent originated colorectal. Additionally, evaluate classical mutations EGFR, KRAS PEACs, it turned out tumors were EGFR-wild KRAS-wild types, confirmed has separate phenotype usual pulmonary adenocarcinoma.