Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas.
作者： Kentaro Inamura , Yukitoshi Satoh , Sakae Okumura , Ken Nakagawa , Eiju Tsuchiya
DOI: 10.1097/01.PAS.0000160438.00652.8B
关键词:
摘要: Primary pulmonary adenocarcinomas with enteric differentiation (PAED) are mainly composed of tall-columnar cells that show similarity to intestinal epithelia and colorectal carcinomas. In this study, we analyzed the immunostaining profiles 7 PAEDs in comparison 14 metastatic carcinomas (MCRs) 30 usual (PACs), using antibodies against CDX-2, cytokeratin (CK7), 20 (CK20), TTF-1, surfactant apoprotein-A (SP-A), Napsin A, MUC2. The positive rates for CK7, CK20, SP-A, MUC2 were 71%, 100%, 43%, 14%, 0%, respectively, PAEDs; 86%, 57% MCRs; 3%, 93%, 73%, 90%, 0% PACs. As expected, immunoreactivity was detected PAEDs. observed decrease or loss A indicates these lesions demonstrate a shift away from their phenotype, although CK7 expression retained. results indicate CK20 may be useful markers distinction MCRs.
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