Breast cancer: origins and evolution
作者： Kornelia Polyak
DOI: 10.1172/JCI33295
关键词: Oncology 、 Cancer stem cell 、 Tumor initiation 、 Breast cancer 、 Biology 、 Disease 、 Epigenetics 、 Epigenesis 、 Internal medicine 、 Somatic evolution in cancer 、 Cancer
摘要: Breast cancer is not a single disease, but rather composed of distinct subtypes associated with different clinical outcomes. Understanding this heterogeneity key for the development targeted cancer-preventative and -therapeutic interventions. Current models explaining inter- intratumoral diversity are stem cell clonal evolution hypotheses. Although tumor initiation progression predominantly driven by acquired genetic alterations, recent data implicate role microenvironmental epigenetic changes as well. Comprehensive unbiased studies tumors patient populations have significantly advanced our molecular understanding breast cancer, translating these findings into practice remains challenge.
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