Multiple types of hydroxyl-rich cationic derivatives of PGMA for broad-spectrum antibacterial and antifouling coatings

摘要: The development of new antibacterial materials is a constant demand in the manufacturing personal hygiene products and medical implements. inhibition bacterial adhesion onto surfaces very challenging, may cause secondary infection. In this study, we synthesize multiple types hydroxyl-rich cationic derivatives via ring-opening reaction star-like poly(glycidyl methacrylate) (s-PGMA) for broad-spectrum antifouling coatings. containing tertiary amine groups are subsequently quaternized to produce poly(quaternary ammonium). quaternary silver-loaded exhibit potent activities towards both Gram-negative Gram-positive bacteria. Particularly, some show 64-fold improvement activity toward P. aeruginosa compared their non-silver counterparts, due synergistic actions ammonium components silver ions. Moreover, can be readily coated on substrates such as glass slides an adhesive layer polydopamine. resultant coatings with rich hydroxyl also endow capability against killed bacteria, while release diffusion ions from polymer enable long-range abilities. This study offers approach synthesizing effective that possess promising applications biomedical devices.