PGMA-based starlike polycations with flanking phenylboronic acid groups for highly efficient multifunctional gene delivery systems
作者： Rui-Quan Li , Hai-Qing Song , Fu-Jian Xu
DOI: 10.1039/C5PY00819K
关键词:
摘要: Phenylboronic acid (PBA) possesses good affinities to glycoproteins on cell surfaces, as well stable fluorescence properties. Recently, it was found that ethanolamine (EA)-decorated poly(glycidyl methacrylate) (PGMA), namely PGEA, exhibited promising applications effective gene vectors. In this work, a strategy prepare series of starlike PGEA vectors (s-PGEA-B) with flanking PBA groups proposed for the development highly efficient multifunctional delivery systems. Compared s-PGEA without groups, corresponding s-PGEA-B counterparts showed greater ability bind pDNA. The sizes formed s-PGEA-B/pDNA nanoparticles were ∼100 nm at higher N/P ratios. complexes enhanced cellular internalization and transfection efficiencies, particularly in lines abundant surface glycoproteins. mediated by 30% content about 85% HepG2 cells, much than (about 53%). addition, simultaneous emitted from provided convenient observation locating during processes. This present work provides new useful information design
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