Bone Mineral Density, 25-OH Vitamin D and Inflammation in Patients with Psoriasis

摘要: BACKGROUND/PURPOSE Low levels of vitamin D may play a role in the pathogenesis psoriasis and is related to increased risk osteoporosis. There are few studies showing rate osteoporosis patients with psoriasis; however, none them investigated impact gender status together. We aimed evaluate relationship between an emphasis on difference. METHODS Forty-three without arthritis 41 healthy controls were enrolled. All <50 years, women premenopausal. Participants questioned about demographic features, sun exposure, regular physical exercise, smoking status. The serum 25-OH D, calcium, phosphorus, C-reactive protein, parathyroid hormone, total alkaline phosphatase, sedimentation measured. Body mass index was calculated. determined bone mineral density lumbar spine femur using dual-energy X-ray absorptiometry. RESULTS Femur neck Z score lower group than those control group. Additionally, femoral score, T, scores female controls, whereas for male subjects there not remarkable difference groups. no significant two groups regarding levels. latter significantly females; males. Patients had higher CRP level rate, subjects. Female also but differences controls. CONCLUSION As has multifactorial etiology, be among triggering or facilitating factors particularly psoriatic via several mechanisms such as low blood inflammation.