Intrinsic bio-signature of gene delivery nanocarriers may impair gene therapy goals.

摘要: Non-viral lipid/polymeric vectors have widely been used as nanocarriers (NCs) for gene delivery. They possess large surface area to volume ratio and are able interact with biomolecules through functional moieties, resulting in inadvertent biological impacts, particular at genomic level. Thus, their bio-signature needs be investigated prior use vivo. Using high-throughput microarray qPCR expression profiling techniques, we reported the impacts of NCs. Given fact that ultimate objectives therapy may inevitably impaired by nonspecific intrinsic these NCs, here, highlight bio-signature. We envision better understanding on genotoxicity delivery guiding premise, will help us develop much safer NCs also accelerate translation into clinical provide pivotal information safety liabilities early discovery developments process its inevitable consequences