Translational Approaches towards Cancer Gene Therapy: Hurdles and Hopes.

摘要: Introduction: Of the cancer gene therapy approaches, silencing, suicide/apoptosis inducing therapy, immunogene and targeted are deemed to sub­stantially control the biological consequences of genomic changes in cancerous cells. Thus, a large number clinical trials have been conducted against various malignancies. In this review, we will discuss recent translational progresses cell of cancer. Methods: Essential information on were reviewed discussed towards their translations. Results: Gene transfer has been rigorously studied vitro vivo, which some these endeavours have carried towards translational investigations applications. About 65% of gene are related therapy. Some trials have combined with produce personalized medicines such as Sipuleucel-T (Provenge®, marketed by Dendreon, USA) for treatment asymptomatic/minimally symptomatic metastatic hormone-refractory prostate cancer. Conclusion: Translational approach links two diverse boundaries basic researches. For successful translation geno­medicines into clinical applications, it is essential 1) guidelines standard operating procedures development application the genomedicines specific clinically relevant biomarker(s); 2) to conduct necessary animal experimental studies show "proof of concept" proposed genomedicines; 3) perform an initial clinical investigation; 4) initiate extensive to address all requirements. short, researches need be refined accelerate geno­medicine and clinical