Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature.
作者： Eseosa T. Ighodaro , Gregory A. Jicha , Frederick A. Schmitt , Janna H. Neltner , Erin L. Abner
DOI: 10.1097/NEN.0000000000000204
关键词: Hippocampal formation 、 Frontotemporal lobar degeneration 、 Epilepsy 、 H&E stain 、 Arteriolosclerosis 、 Hippocampal sclerosis 、 Alzheimer's disease 、 Pathology 、 Gliosis 、 Neuroscience 、 Psychology
摘要: Hippocampal sclerosis of aging (HS-Aging) is a neurodegenerative disease that mimics Alzheimer (AD) clinically and has prevalence rivaling AD in advanced age. Whereas clinical biomarkers are not yet optimized, HS-Aging distinctive pathological features distinguish it from other diseases with “hippocampal sclerosis” pathology, such as epilepsy, cerebrovascular perturbations, frontotemporal lobar degeneration. By definition, brains show neuronal cell loss gliosis the hippocampal formation out proportion to AD-type pathology; strongly associated aberrant TDP-43 pathology arteriolosclerosis. Here, we describe 2 cases “segmental” which “sclerosis” hippocampus was evident only subset brain sections by hematoxylin eosin (H&E) stain. In these cases, more widespread on immunostained than seen H&E stains. The patients were cognitively intact at baseline tracked longitudinally over decade using cognitive studies least 1 neuroimaging scan. We discuss relevant literature, indicates need for clearer consensus-based delineation pathologies aged subjects.
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