Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs.
作者： Erum Jabeen , Rumana Qureshi , Afzal Shah
DOI: 10.1016/J.JPHOTOBIOL.2013.06.002
关键词: Absorption (skin) 、 Acetaminophen 、 Sodium 、 Anti-inflammatory 、 Acetazolamide 、 Pharmacology 、 Chemistry 、 Nonsteroidal 、 Aspirin 、 Pharmacokinetics
摘要: Abstract The binding of antihypertensive acetazolamide with eleven nonsteroidal anti-inflammatory drugs (NSAIDs) was investigated at pH 3, 7 and 9.5 the objective monitoring their interactive pharmacokinetics during digestion absorption in human body. results UV–Vis spectroscopy cyclic voltammetry revealed two NSAIDs (acetaminophen dichlofenic sodium) to interact stomach fluid conditions forming complexes 1:1 1:2 stoichiometry. complexation ratio also verified by computational methods. strong propensity acetaminophen sodium prohibited combined therapy. However, poor affinity aspirin mefinamic acid suggested these as preferred be prescribed acetazolamide.
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