Study of physicochemical parameters affecting the release of diclofenac sodium from lipophilic matrix tablets

摘要: In the present work different parameters, which influence release of diclofenac sodium (2-[(2,6-dichlorophenyl)amino]benzeneacetic acid mono salt) from lipophilic matrix prolonged tablets, were investigated. Solubility characteristics in aqueous media with various ionic strengths, compositions and pH range 1 to 10 determined. According obtained results experimental conditions dissolution test on drug profiles studied, i.e. apparatus, rotation speeds stirring elements, buffer a 5.8 10.0 strengths. The amount released was determined by ultraviolet spectrophotometry at wavelength maximum absorbance 276 ′ 2 nm. From it can be concluded, that solubility depends mainly composition medium also strengths medium. Besides these tablets type apparatus particularly elements.