Electrospun Poly(L-lactide) Membranes Containing a Single Drug or Multiple Drug System for Antimicrobial Wound Dressings
作者： Antoniya Toncheva , Dilyana Paneva , Nevena Manolova , Iliya Rashkov
DOI: 10.1007/S13233-011-1206-0
关键词: Membrane 、 PEG ratio 、 Materials science 、 Ethylene glycol 、 Contact angle 、 Benzalkonium chloride 、 Hydrophilization 、 Nuclear chemistry 、 Antibacterial activity 、 Polymer chemistry 、 Electrospinning
摘要: Micro- and nanofibrous electrospun poly(L-lactide) (PLA) PLA/poly(ethylene glycol) (PEG) membranes containing diclofenac sodium (DS), lidocaine hydrochloride (LHC), benzalkonium chloride (BC), or combinations thereof (DS/LHC DS/LHC/BC) have been developed. The addition of low molecular weight organic salts to the spinning PLA PLA/PEG solutions results in increased conductivity contributes preparation composed fibers that are well-aligned with collector rotation direction. water contact angle values characteristic hydrophobic surfaces. incorporation LHC does not lead membrane hydrophilization. In contrast LHC, other drugs led hydrophilic fibrous materials. hydrophilization is due presence DS BC fragments functional groups on surfaces as verified by X-ray photoelectron spectroscopy (XPS). As evidenced differential scanning calorimetric study diffraction analysis data, incorporated amorphous state. release profiles DS, from PLA/drug PLA/PEG/drug depend drug nature and, case BC, composition polymer scaffold well. PLA/DS/LHC PLA/PEG/DS/LHC slower compared single drug-loaded membranes. This phenomenon has attributed an ionic interaction between two drugs. Microbiological studies demonstrated PLA/DS, PLA/BC, PLA/DS/LHC, PLA/DS/LHC/BC exhibit antibacterial activity against Staphylococcus aureus. Open image new window
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koreascience.or.kr 参考文章(29)
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