Drug release characteristics from nanoclay hybrids and their dispersions in organic polymers.

摘要: This study establishes and compares structure-property-processing relationships on three drug delivery systems containing an anionic active pharmaceutical ingredient (API) in the following excipient carriers: (a) inorganic nanoclay, (b) pH responsive acrylic polymers, (c) combinations thereof. The effects of excipients APIs dissolution rate were studied from their release profile simulated body fluids (SBFs) with different pH. In API-nanoclay system, calcination clay followed by its reconstitution API solution was successfully used to intercalate amorphous state clay. As a result, showed increased apparent solubility vs. crystalline form mechanism being predominantly diffusion controlled depending SBFs. melt mixed ternary polymer above hybrids, as result additional diffusional step due presence nanoplatelets, more that contained only API. By comparison low SBF, system 7.4 SBF reduced contribution platelets, latter unaffected high value. Reasonable agreement found predictions literature diffusion/erosion models. It is confirmed hot mixing offers opportunities produce enhanced solubility. nanoclays can also increase API's affect manner.