Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children.
作者： Wei Jia , Jinhong Zhu , Wen Fu , Shibo Zhu , Fuming Deng
DOI: 10.1155/2019/3518149
关键词: Gene 、 Renal tumor 、 Medicine 、 Odds ratio 、 Confidence interval 、 Wilms' tumor 、 Internal medicine 、 Genetic etiology 、 Oncology 、 Genotype 、 Statistical significance
摘要: Wilms’ tumor is renal of childhood, characterized by the appearance embryonic tissue and other kidney malformations. The genetic etiology sporadic remains largely unknown. Neurofilament light (NEFL) a suppressor. We evaluated association between three NEFL gene polymorphisms (rs11994014 G>A, rs2979704 T>C rs1059111 A>T) susceptibility in Chinese population consisting 145 cases 531 controls. In single locus analysis, CC variant genotype was associated with decreased risk [CC vs. TT: adjusted odds ratio (OR)=0.48, 95% confidence interval (CI)=0.24-0.94; TT+CT: OR=0.51, CI=0.27-0.97]. also observed that carriers protective genotypes had significantly when compared to those 0-2 (adjusted OR=0.49, CI=0.25-0.95). rs11994014 G>A or A>T did not reach statistical significance. No significant detected stratified analyses. Our findings suggested polymorphism may be population.
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