Apigenin ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1

摘要: The abuse of fructose in daily diet may cause cardiovascular diseases that seriously threaten human health, and both safe efficient solutions need to be developed. We investigated whether apigenin can prevent the harmful impact excessive on events. Based reduction percentage body fat systolic pressure as well improvements insulin resistance, lipid metabolism, pathological injury thoracic aorta, we suggested high levels vascular metabolic disorders, which improved some extent by using apigenin. Fundamentally, down-regulates phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), glucose transporter 1 (GLUT1), increase with concentrations fructose. Moreover, inflammation asymmetric dimethylarginine (ADMA) increased group, but they decreased when rats were fed results suggest PI3K/AKT/GLUT1 have potential for alleviating injury, an excellent candidate supplements ameliorate related consumption.