VEGF and MVD expression in sinus augmentation with autologous bone and several graft materials.
作者： RJ Boëck-Neto , L Artese , A Piattelli , JA Shibli , V Perrotti
DOI: 10.1111/J.1601-0825.2008.01502.X
关键词: Calcium 、 Angiogenesis 、 Surgery 、 Sinus Floor Augmentation 、 Urology 、 Neovascularization 、 Vascular endothelial growth factor 、 Maxillary sinus 、 Sinus (anatomy) 、 Medicine 、 Mature Bone
摘要: Objective: The aim of this study was to assess vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in maxillary sinus augmentation with autogenous bone different graft materials for evaluating their angiogenic potential. Methods: Biopsies were harvested 10 months after a combination materials: hydroxyapatite (HA, n = 6 patients), demineralized freeze-dried allograft (DFDBA, n = 5 calcium phosphate (CP, Ricinus communis polymer (n = 5 patients) control group – only (n = 13 patients). Results: In all the samples, higher intensities VEGF prevalent newly formed bone, while lower predominant areas mature bone. highest intensity expressed by HA (P < 0.001) CP relation (P < 0.01) groups. lowest shown DFDBA groups (P < 0.05). When comparing grafting materials, MVD found around control, (P < 0.001). Conclusion: Various could be successfully used floor augmentation; however, interactions between formation angiogenesis remain fully characterized.
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