Substructures of paired helical filaments from Alzheimer's disease neurofibrillary tangles.
作者： H. M. Wisniewski , G. Y. Wen
DOI: 10.1007/BF00688696
关键词: Materials science 、 Pathology 、 Paired helical filaments 、 Neurofilament 、 Nuclear magnetic resonance
摘要: Presented studies reveal that each of the approximately 10 nm filaments forming paired helical (PHF) is made up four protofilaments. Each protofilaments a beaded structure, consisting globules connected by longitudinal bars. A cross-view PHF shows eight linked transverse The bars are shorter than Comparison between and neurofilament indicates structural differences these profiles, i.e., making larger longer those in normal neurofilaments. three-dimensional diagram structure presented.
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