Disorazol A, an Efficient Inhibitor of Eukaryotic Organisms Isolated from Myxobacteria
作者： HERBERT IRSCHIK , ROLF JANSEN , KLAUS GERTH , GERHARD HÖFLE , HANS REICHENBACH
DOI: 10.7164/ANTIBIOTICS.48.31
关键词: Biochemistry 、 Strain (chemistry) 、 Antibiotics 、 Biological activity 、 Oxazole 、 Biology 、 Biosynthesis 、 Microbiology 、 Myxobacteria 、 Sorangium cellulosum 、 Bacteria
摘要: A new antibiotic, disorazol, was isolated from the culture broth of myxobacterium, Sorangium cellulosum strain So ce 12. It is a macrocyclic compound containing two oxazole rings. The antibiotic acted against many fungi and mammalian cell cultures. latter responded to extremely low doses (MIC 3-30 pg/ml). None tested bacteria yeasts were inhibited.
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