Effect of a cooked meat meal on serum creatinine and estimated glomerular filtration rate in diabetes related kidney disease

摘要: OBJECTIVE Fasting is not routinely recommended for renal function tests, despite the known effects of cooked meat on creatinine. We therefore studied variation in creatinine and estimate glomerular filtration rate (eGFR) following a standardised meal 80 subjects: healthy volunteers, diabetes patients with chronic kidney disease (CKD) stages 1 & 2, 3A, 3B 4 (n=16/group). RESEARCH DESIGN AND METHODS The interventions were non-meat meal, each providing approximately 54g protein, together 250 mls water, separate days. post-prandial blood samples at 1, hours drawn measurement using kinetic alkaline picrate assay an Olympus AU640 analyser. modified 4-variable MDRD equation traceable to isotope dilution mass spectrometry was used calculate eGFR. RESULTS Consumption significantly increased serum resulted significant fall eGFR all CKD studied; 6 16 3a misclassified as 3b. This effect disappears after 12 fasting study participants. CONCLUSIONS Creatine converted cooking which absorbed causing increases could impact management threshold commencing withdrawing certain medications expensive investigations defined by calculated would be better reflection these patients.