Repeated administration of diphenyl diselenide to pregnant rats induces adverse effects on embryonic/fetal development
作者： Simone N Weis , Alexandre M Favero , Eluza C Stangherlin , Flavia G Manarin , Joao BT Rocha
DOI: 10.1016/J.REPROTOX.2006.09.008
关键词: Diphenyl diselenide 、 Endocrinology 、 Embryogenesis 、 Fetal Skeleton 、 Toxicity 、 Weight gain 、 Fetus 、 Gestation 、 Pregnancy 、 Internal medicine 、 Medicine
摘要: Abstract The present study was carried out to investigate the effects of diphenyl diselenide, (PhSe)2, on embryo-fetal development. Dams were treated subcutaneously with 1.5, 3.0 and 6.0 mg/kg (PhSe)2 from days 6 15 pregnancy. After cesarean section at gestation day (GD) 20, external skeletal abnormalities evaluated. A decrease in maternal body weight gain found groups, indicating toxicity. There a reduction fetal crown-rump (CR) length fetuses three doses tested. occipito-nasal decreased dams exposed 3.0 mg/kg (PhSe)2. Signs delayed ossification skull, sternebrae limbs observed all revealing relation between morphological alterations growth retardation fetuses, but none changes appeared be dose-dependent. Exposure resulted altered placental morphology that may have contributed adverse reproductive outcomes. We concluded is toxic induces developmental delay skeleton, does not cause externally visible malformations rat this experimental procedure.
elsevier.com
sci-hub.se 参考文章(33)
Makoto Usami, Hirobumi Tabata, Yasuo Ohno, Effects of ascorbic acid on selenium teratogenicity in cultured rat embryos Toxicology Letters. ,vol. 105, pp. 123- 128 ,(1999) , 10.1016/S0378-4274(98)00394-4
Rogelio E. Perez-D'Gregorio, Richard K. Miller, Teratogenicity of tellurium dioxide: Prenatal assessment Teratology. ,vol. 37, pp. 307- 316 ,(1988) , 10.1002/TERA.1420370404
Lucielli Savegnago, Marcio Trevisan, Diego Alves, Joao Batista Teixeira Rocha, Cristina W. Nogueira, Gilson Zeni, Antisecretory and antiulcer effects of diphenyl diselenide Environmental Toxicology and Pharmacology. ,vol. 21, pp. 86- 92 ,(2006) , 10.1016/J.ETAP.2005.07.017
Francielli W Santos, Gilson Zeni, Joao BT Rocha, Simone N Weis, Juliana M Fachinetto, Alexandre M Favero, Cristina W Nogueira, None, Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues. Chemico-Biological Interactions. ,vol. 151, pp. 159- 165 ,(2005) , 10.1016/J.CBI.2005.01.001
E. N. Maciel, E. M. M. Flores, J. B. T. Rocha, V. Folmer, Comparative deposition of diphenyl diselenide in liver, kidney, and brain of mice. Bulletin of Environmental Contamination and Toxicology. ,vol. 70, pp. 470- 476 ,(2003) , 10.1007/S00128-003-0010-8
R.S. Bedwal, N. Nair, M.P. Sharma, R.S. Mathur, Selenium—Its biological perspectives Medical Hypotheses. ,vol. 41, pp. 150- 159 ,(1993) , 10.1016/0306-9877(93)90062-U
R. S. Bedwal, A. Bahuguna, Zinc, copper and selenium in reproduction Cellular and Molecular Life Sciences. ,vol. 50, pp. 626- 640 ,(1994) , 10.1007/BF01952862
Ashley King, Yung Wai Loke, On the nature and function of human uterine granular lymphocytes Immunology Today. ,vol. 12, pp. 432- 435 ,(1991) , 10.1016/0167-5699(91)90014-K
F.C Meotti, E.C Stangherlin, G Zeni, C.W Nogueira, J.B.T Rocha, Protective role of aryl and alkyl diselenides on lipid peroxidation Environmental Research. ,vol. 94, pp. 276- 282 ,(2004) , 10.1016/S0013-9351(03)00114-2
M. A. SHARIFF, C. R. KRISHNAMURTI, A. L. SCHAEFER, A. M. HEINDZE, BIDIRECTIONAL TRANSFER OF SELENIUM ACROSS THE SHEEP PLACENTA IN UTERO Canadian Journal of Animal Science. ,vol. 64, pp. 252- 254 ,(1984) , 10.4141/CJAS84-248