Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy.

摘要: PURPOSETo evaluate prospectively the efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) in reduction chemotherapy-induced oral mucositis.PATIENTS AND METHODSTwenty patients with stage IV squamous cell carcinoma head and neck were studied. Two-cycles (periods) identical doses cisplatin, fluorouracil (5-FU), leucovorin (PFL) chemotherapy cisplatin 20 mg/m2/d, 5-FU 800 90 mg/m2/d by 96-hour continuous intravenous infusion every 3 weeks given to each patient. After PFL chemotherapy, GM-CSF 4 micrograms/kg subcutaneously from days 5 14 or no therapy was a randomized self-controlled crossover study design. Oral mucositis graded modified Radiation Therapy Oncology Group criteria.RESULTSIn first cycle significantly reduced incidence, mean duration, area under curve (AUC) severe gross (grade > = 3) compared therapy. These beneficial effects continue...