Luteotrophic and luteolytic effects of nitric oxide in sheep are dose-dependent in vivo
作者： Christopher S. Keator , David T. Schreiber , Thomas A. Hoagland , John A. McCracken
DOI: 10.1016/J.DOMANIEND.2008.02.001
关键词: Endocrinology 、 Luteolytic Effects 、 Dose–response relationship 、 Venous Plasma 、 In vivo 、 Internal medicine 、 Corpus luteum 、 Nitric oxide 、 Dipropylenetriamine-NONOate 、 Luteal phase 、 Chemistry
摘要: It has been suggested that nitric oxide (NO) acts in either an anti-luteolytic or a luteolytic manner, but the mechanism for these opposing roles is unclear. We hypothesized NO may act dose-dependent manner to regulate luteal function, whereby low concentrations of might stimulate progesterone production (i.e. luteotrophic) and high reduce plasma luteolytic). To test this hypothesis we infused increasing fast-acting donor, dipropylenetriamine NONOate (DPTA), into arterial supply sheep with ovarian transplants bearing corpus luteum (CL). Infusions were performed on CL 11 days age (n=9) over 30 (n=15). measured changes concentration venous during 1-h infusion 24h after infusion, then compared mean between treatment groups effects by dose period interactions. Compared saline-treated controls (n=6), highest 1000 microg/min DPTA (n=6) reduced (P 0.05) lowest 1 controls. conclude regulates function vivo.
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