CYP2D6 Genotype, Antidepressant Use, and Tamoxifen Metabolism During Adjuvant Breast Cancer Treatment

作者: Y. Jin , Z. Desta , V. Stearns , B. Ward , H. Ho

DOI: 10.1093/JNCI/DJI005

关键词: Serotonin reuptake inhibitorTamoxifenBiologyEndocrinologyMetaboliteCYP2D6AntiestrogenGenotypeCYP2C9Breast cancerPharmacologyInternal medicine

摘要: … genotypes on plasma concentrations of tamoxifen and its metabolites, we combined the subjects who were *1/*3, *1/*4, *1/*5, or *1/*6 heterozygotes together into a wild-type/variant …

参考文章(34)
Martin Hersberger, Jacqueline Marti-Jaun, Katharina Rentsch, Edgar Hänseler, Rapid Detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 Alleles by Tetra-Primer PCR and of the CYP2D6*5 Allele by Multiplex Long PCR Clinical Chemistry. ,vol. 46, pp. 1072- 1077 ,(2000) , 10.1093/CLINCHEM/46.8.1072
Andrea Decensi, Sara Gandini, Aliana Guerrieri-Gonzaga, Harriet Johansson, Lapo Manetti, Bernardo Bonanni, Maria Teresa Sandri, Antonella Barreca, Alberto Costa, Chris Robertson, Ernst A. Lien, Effect of blood tamoxifen concentrations on surrogate biomarkers in a trial of dose reduction in healthy women. Journal of Clinical Oncology. ,vol. 17, pp. 2633- 2638 ,(1999) , 10.1200/JCO.1999.17.9.2633
Zeruesenay Desta, Bryan A. Ward, Nadia V. Soukhova, David A. Flockhart, Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. Journal of Pharmacology and Experimental Therapeutics. ,vol. 310, pp. 1062- 1075 ,(2004) , 10.1124/JPET.104.065607
Masahiro Hiratsuka, Yoh Takekuma, Naomi Endo, Kaori Narahara, Samar Hamdy, Yukinaga Kishikawa, Masaki Matsuura, Yasuyuki Agatsuma, Tomoko Inoue, Michinao Mizugaki, Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population European Journal of Clinical Pharmacology. ,vol. 58, pp. 417- 421 ,(2002) , 10.1007/S00228-002-0499-5
C. L. Loprinzi, Phase III Evaluation of Fluoxetine for Treatment of Hot Flashes Journal of Clinical Oncology. ,vol. 20, pp. 1578- 1583 ,(2002) , 10.1200/JCO.20.6.1578
Lynne M Bang, Gillian M Keating, Paroxetine Controlled Release CNS Drugs. ,vol. 18, pp. 355- 364 ,(2004) , 10.2165/00023210-200418060-00003
Guangping Chen, Shuhua Yin, Smarajit Maiti, Xiuping Shao, 4-Hydroxytamoxifen sulfation metabolism. Journal of Biochemical and Molecular Toxicology. ,vol. 16, pp. 279- 285 ,(2002) , 10.1002/JBT.10048
Kyung-Hoon Lee, Bryan A. Ward, Zeruesenay Desta, David A. Flockhart, David R. Jones, Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial. Journal of Chromatography B. ,vol. 791, pp. 245- 253 ,(2003) , 10.1016/S1570-0232(03)00218-6
Andrea Gaedigk, R. Russell Gotschall, Nataŝa S. Forbes, Stephen D. Simon, Gregory L. Kearns, J. Steven Leeder, Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data Pharmacogenetics and Genomics. ,vol. 9, pp. 669- 682 ,(1999) , 10.1097/01213011-199912000-00002