Ganglioside-basic protein interaction: protection of gangliosides against neuraminidase action.
作者： H. C. Yohe , Ronald I. Jacobson , Robert K. Yu
关键词: Myelin 、 Ganglioside 、 Precipitin 、 Myelin basic protein 、 Clostridium perfringens 、 Sphingolipid 、 Biology 、 Neuraminidase 、 Major basic protein 、 Biochemistry
摘要: The ability of acidic phospho- and sphingolipids to interact with basic proteins was studied by double diffusion analysis. phospholipids, tri- diphosphoinositide, the sphingolipid, sulfatide, interacted myelin protein as evidenced precipitin line formation. Of sialoglycosphingolipids (gangliosides) tested, only myelin-specific monosialoganglioside, GM41 , formed a protein. In addition, retarded activity Clostridium perfringens neuraminidase against GM4 disialoganglioside, GD1b. Examination purified rat brain suggested presence intrinsic myelin. This finding, in concert ganglioside-myelin complexes which selectively protect neuraminidase, may provide physiological explanation for simplified ganglioside pattern found
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sci-hub.se 参考文章(35)
H. McIlwain, Characterization of naturally occurring materials which restore excitability to isolated cerebral tissues Biochemical Journal. ,vol. 78, pp. 24- 32 ,(1961) , 10.1042/BJ0780024
S Ando, R K Yu, Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain. Journal of Biological Chemistry. ,vol. 252, pp. 6247- 6250 ,(1977) , 10.1016/S0021-9258(17)39945-3
Lars Svennerholm, Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochimica et Biophysica Acta. ,vol. 24, pp. 604- 611 ,(1957) , 10.1016/0006-3002(57)90254-8
P. C. Emson, B. M. H. Bush, M. H. Joseph, Gangliosides of peripheral nerve myelin. Journal of Neurochemistry. ,vol. 26, pp. 157- 162 ,(1976) , 10.1111/J.1471-4159.1976.TB04451.X
Robert W. Ledeen, Robert K. Yu, Gangliosides: structure, isolation, and analysis. Methods in Enzymology. ,vol. 83, pp. 139- 191 ,(1982) , 10.1016/0076-6879(82)83012-7
H.C. Yohe, R.K. Yu, In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a. Journal of Biological Chemistry. ,vol. 255, pp. 608- 613 ,(1980) , 10.1016/S0021-9258(19)86219-1
Frederick B. Cochran, Robert W. Ledeen, Robert K. Yu, Gangliosides and proteins in developing chicken brain myelin. Developmental Brain Research. ,vol. 6, pp. 27- 32 ,(1982) , 10.1016/0165-3806(82)90171-7
D. A. Booth, THE ISOLATION AND ASSAY OF GANGLIOSIDES AND THEIR INTERACTIONS WITH BASIC PROTEINS Journal of Neurochemistry. ,vol. 9, pp. 265- 276 ,(1962) , 10.1111/J.1471-4159.1962.TB09448.X
Frederick B. Cochran, Robert K. Yu, Susumo Ando, Robert W. Ledeen, Myelin gangliosides: an unusual pattern in the avian central nervous system. Journal of Neurochemistry. ,vol. 36, pp. 696- 702 ,(1981) , 10.1111/J.1471-4159.1981.TB01644.X
Kunihiko Suzuki, Joseph F. Poduslo, Shirley E. Poduslo, Further evidence for a specific ganglioside fraction closely associated with myelin Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 152, pp. 576- 586 ,(1968) , 10.1016/0005-2760(68)90098-2