Prevention of experimental allergic encephalomyelitis by ganglioside GM4: A follow-up study
作者： Brian R. Mullin , Darryl H. Patrick , Charles M.B. Poore , Bonnie H. Rupp , Michael T. Smith
DOI: 10.1016/0022-510X(86)90063-8
关键词:
摘要: The myelin-specific ganglioside GM4, when incubated with myelin basic protein prior to inoculation, prevents experimental allergic encephalomyelitis in the guinea pig. monosialoganglioside GM1, predominant of mammalian myelin, also encephalomyelitis, whereas a mixture neural gangliosides rich polysialogangliosides causes enhanced disease. Guinea pigs inoculated both and GM4 develop serum IgG antibodies against protein, but not GM4.
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