Effects of gangliosides on the expression of autoimmune demyelination in the peripheral nervous system.

摘要: To test whether gangliosides (GA) might exert neuritogenic effects in vivo, experimental allergic neuritis (EAN) was studied clinically, neuropathologically, and immunologically Lewis rats immunized with bovine peripheral nerve, P2 myelin protein, protein plus two different doses of GA, galactocerebroside (GC), GA alone, each emulsified adjuvant. All except the GA-treated group developed signs EAN between days 11 14 after injection. Rats alone were most severely affected. given those GC displayed a significantly lower clinical score. Histological analysis revealed comparable degree inflammation nervous system demyelination spinal nerve roots nerve- P2-immunized rats. The groups similar degrees pathology but latter stood apart from rest that it showed widespread changes extending distally into sciatic nerve. Serological demonstrated GC, not elicited antibody (IgG) responses, there no correlation titer or histological involvement. present data fail to support an enhancing role for expression and, by extrapolation, Guillain-Barre syndrome, which serves as laboratory model, suggestions have been made antibodies may pathogenetic significance.